SARS-CoV-2 Antigens

Sequence and structure of the new coronavirus SARS-CoV-2 have been well studied and described. Of particular interest with respect to diagnostics and drug development are the spike protein (S-protein), due to its role in the interaction with human host receptors, and the highly conserved nucleocapsid protein (N-protein) with high immunogenicity.

At BIOZOL you can obtain recombinant S- and N-proteins from different expression systems as well as suitable antibodies and assays.

 

SARS-CoV-2 Spike-Protein (S-Protein)

The spike protein on the surface of the virus envelope is the most important target for neutralizing antibodies and vaccines. It consists of two subunits, S1 and S2.
S1 contains the receptor binding domain (RBD), which is responsible for recognition and binding of the cell surface receptor (in human respiratory epithelial cells ACE2).
The S2 subunit is required for membrane fusion.

Figure: PDB 6VXX, Structure of the SARS-CoV-2 spike glycoprotein (closed state), Mol*

 

Selected recombinant SARS-CoV-2 S-Proteins in our web shop:

>> full-length S-Protein and subunits (S1, S2, S1 RBD) from Sino Biological
>> HEK293 expressed S1 and S2 glycoproteins from The Native Antigen Company
>> Spike-Protein S1 RBD from Signalchem, expressed in CHO cells

 

SARS-CoV-2 Nucleocapsid Protein (N-Protein)

The nucleocapsid protein is the most detectable protein in coronaviruses. It is a highly immunogenic phosphoprotein and normally highly conserved. The N protein is therefore often used as a marker in diagnostic assays.

Selected recombinant SARS-CoV-2 N-Proteins in our web shop:

>> GeneTex SARS-CoV-2 Nucleocapsid Protein (GTX135357-PRO)
>> ABM SARS-CoV-2 Nucleocapsid Protein, recombinant (BZL-CK6404-b-1)
>> Coronavirus 2019 Nucleocapsid, recombinant from Biovendor