Recombinant Selenoprotein Production
Expression of active and selenocysteine-containing proteins
Express and buy your selenoprotein of choice
At BIOZOL you can buy more than 25 selenoproteins directly. After request you even have have access to all 837 selenoproteins yet identified in nature, as well as synthetic selenoproteins tailored to your requirements.
In humans, there are 25 selenoproteinencoding genes, which are involved in diverse metabolic and physiological functions ranging from antioxidant defense to fertility, muscle development and function, thyroid hormone metabolism, and immune function. Several selenoproteins also have major importance in cancer, both as enzymes protecting cells from carcinogenesis and as target proteins for anticancer drug therapies. Consequently, the range of pathologies associated with primary or secondary defects in selenoprotein functions are many.
All selenoproteins contain a rare amino acid, selenocysteine, which has limited their use in research, therapy and diagnostics. Up until now, customers have been forced to purchase either inactive selenoproteins, lacking the essential selenocysteine residue, or active selenoproteins obtained from animal sources, being expensive, ethically questionable and providing very low yields.
Since all selenoproteins by definition contain the rare amino acid Selenocysteine (Sec), it has previously been very hard to obtain them in pure form or to produce them recombinantly, due to the complex genetic system required for co-translational Sec insertion.
To provide you the best service for recombinant expression of active selenoproteins, BIOZOL works closely with SeLENOZYME.
Here you get the opportunity to express and buy the selenoprotein of your choice!
SeLENOZYME - a unique world-wide provider of recombinant selenoproteins
SeLENOZYME uses a cutting-edge technology, resulting from over 30 years of research at Karolinska Institutet in Stockholm, Sweden. Their recombinant system allows them to produce purified and active selenoproteins from human and most other naturally occurring selenoproteins, or other tailored synthetic selenocysteine-containing proteins. At present SeLENOZYME has more than 25 selenoproteins in their portfolio. After request SeLENOZYME has the ability to produce all 837 selenoproteins yet identified in nature, as well as synthetic selenoproteins tailored to customer requirements.
SeLENOZYME's recombinant production system uses bacteria instead of mammalian cells, making the production of active selenoproteins more effective and cost-efficient. Furthermore, they have established a state-of-the-art protein production facility to supply researchers and development departments with selenoproteins at any desired scale and purity and at very competitive prices compared to selenoproteins purified from native sources.
All catalog selenoproteins and SeLENOZYME's recombinant selenoprotein production service are available from BIOZOL.
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