Tumor Markers

Recombinant Engineered Antibodies from Absolute Antibody

Absolute Antibody specializes in antibody sequencing, engineering and recombinant expression, offering royalty-free custom services and a unique reagents catalog of engineered recombinant antibodies and Fc Fusion proteins. These Antibodies are available for tumor marker antigens, neuroscience and virology research. Absolute Antibody's VivopureX™ antibodies are recombinant mouse antibodies ideal for in vivo research in mouse models.

Recombinant Engineered Antibodies

The vast majority of reagent monoclonal antibodies are generated from hybridomas, immortal antibody-producing cells created by fusing a tumor (myeloma) cell with an antibody-producing B cell from an immunized animal. However, hybridomas suffer from many limitations. They can undergo genetic drift, leading to batch-to-batch variability; they can be genetically unstable and stop expressing the antibody; and more than 30% of hybridomas contain additional antibody genes, meaning they are not actually monoclonal.

In contrast, recombinant antibodies are manufactured using synthetic genes expressed in a defined in vitro cell line. They offer a variety of benefits compared to traditional hybridoma-produced antibodies:

Ensured reproducibility: defined by amino acid sequence, ensuring batch-to-batch reproducibility
Biological definition: reliable binding specificity, affinity and reproducibility, no variation in heavy or light chains
High purity: expressed in a chemically defined, serum-free mammalian expression system
Added antibody value: enabling antibody engineering and the production of custom antibodies
Animal-free manufacturing: manufactured in vitro using synthetic genes, an entirely animal-free process
Security: not susceptible to contamination, genetic drift or accidental loss

Absolute Antibody specializes in antibody sequencing, engineering, and recombinant expression, offering advanced technologies and manufacturing capabilities to meet the growing global demand for recombinant antibodies. At its ISO-certified facility, the company uses its proprietary HEXpress™ expression platform to produce high-quality recombinant antibodies in virtually any species, isotype, or format, from milligram to multi-gram scale within just a few weeks.

This platform has enabled the production of more than 23,000 recombinant antibodies and supports a catalog of over 15,000 engineered antibody products available in a wide range of off-the-shelf formats. Absolute Antibody also provides sophisticated antibody engineering services, including humanization, bispecific and trispecific antibody design, Fc modification, and proprietary technologies such as Fc Silent™, AbFab2™, and Prometheus™. In addition, the company offers high-throughput hybridoma sequencing and protein sequencing services to secure and preserve valuable antibody sequences, having successfully sequenced more than 5,000 hybridomas to date.

Tumor Marker Antibodies

Tumor antigens serve as important tumor markers and can be used as targets in the detection and treatment of cancer. Antibodies targeting these tumor markers may have diagnostic applications in detection of the presence, type and stage of cancer. They also form an important class of therapeutic antibodies.

Absolute Antibody offers a large catalog of 75+ tumor marker antigen antibodies, including anti-TAA (tumor associated antigens) and anti-TSA (tumor specific antigens). They have used their recombinant antibody technology and antibody engineering to generate different engineered formats of these antibodies for all your experimental needs.

Highlights of Absolute Antibody's tumor marker antigens include:

Engineer antibodies into any species and with any effector function
Fc Silent™ formats help to eliminate antibody directed cytotoxicity (ADCC) effector function of Fc receptors
Create bispecific antibodies on human or mouse background
Recombinantly produced to ensure batch-to-batch reproducibility
Low endotoxin levels and high purity for in vivo and in vitro research

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