Influenza

Recombinant Antigens for 2015-2026 Vaccine Strains

Seasonal flu is a common infectious disease of the respiratory tract caused by influenza virus. There are four types of influenza virus, influenza type A, B, C, and D. The A and B types are of most interest to the medical community because they are the culprits for seasonal epidemics. Vaccination is the most effective way to prevent flu infection.

Each year, several different flu strains are selected as vaccine candidates based on surveillance data of the recent isolates and the performance of the vaccines from the previous season. In recent decades, most influenza vaccines are trivalent or quadrivalent, composed of one H1N1, one H3N2, and either one or two type B viruses (Yamagata and Victoria lineage).

Our partner Sino Biological offers recombinant flu antigen products under its ProVir® viral antigen collection. The product line covers Hemagglutinin (HA), Neuraminidase (NA), and Nucleoprotein (NP) proteins, from all WHO-recommended vaccine strains in recent years. These antigens can be used to analyze vaccine-induced antibody response. In addition, Sino Biological also develops a large collection of monoclonal antibodies against the flu antigens. These reagents can help facilitate relevant assay development.

Influenza Vaccine Strains Year 2025-2026

A/Victoria/4897/2022 (H1N1) Recommended for Egg-based (trivalent) Vaccine
HA1: SIN-40938-V08H3	NA: SIN-40939-V08B
HA: SIN-40938-V08H, SIN-40938-V08B	NP: SIN-40962-V08B
HA-Specific B cell probe: SIN-41049-V27H-B	Biotinylated HA: SIN-40938-V49H-B (pre-order)

A/Croatia/10136RV/2023 (H3N2) Recommended for Egg-based (trivalent) Vaccine
HA1: SIN-41058-V08H1	NP: SIN-41077-V08E
HA: SIN-41058-V08B, SIN-41058-V08H	Biotinylated HA: SIN-41058-V49H-B (pre-order)
NA: SIN-40991-V08B

B/Austria/1359417/2021 (B/Victoria lineage) Recommended for Egg-based, Cell culture-, recombinant protein- or nucleic acid-based (trivalent) Vaccine
HA1: SIN-40862-V08H3	NA: SIN-40863-V08B
HA: SIN-40862-V08B, SIN-40862-V08H	NP: SIN-40861-V08B
HA Trimer: SIN-40862-V08H2	Biotinylated HA: SIN-40862-V49H-B (pre-order)

A/Wisconsin/67/2022 (H1N1) Recommended for Cell culture-, recombinant protein- or nucleic acid-based (trivalent) Vaccine
HA1: SIN-40940-V08H8	NA: SIN-40941-V08B
HA: SIN-40940-V08H, SIN-40940-V08B	NP: SIN-40942-V08B
HA Trimer: SIN-40940-V08H7	Biotinylated HA: SIN-40940-V49H8-B

B/Phuket/3073/2013 (B/Yamagata lineage) Recommended for Egg-based, Cell- or recombinant-based (quadrivalent) Vaccine
HA1: SIN-40498-V08H1	NA: SIN-40502-V07B
HA: SIN-40498-VNAB, SIN-40498-V08B	NP: SIN-40500-V08B
HA Trimer: SIN-40498-V08H12

A/District of Columbia/27/2023 (H3N2) Recommended for Cell culture-, recombinant protein- or nucleic acid-based (trivalent) Vaccine
HA1: SIN-41056-V08H1	NP: SIN-41077-V08E
HA: SIN-41056-V08B, SIN-41056-V08H	Biotinylated HA: SIN-41056-V49H-B (pre-order)
NA: SIN-41055-V08B