Complement System

WIESLAB® Functional Assays from Svar

Svar is a Swedish life science company that invent, develop and apply the best assay technology for drug development and clinical diagnostics with the goal to deliver new solutions tailored to customer requirements.

For complement system research they offer functional and biomarker assays that can be used to explore every angle of complement system-involvement in a wide range of application areas.

 

The Complement System

The complement system is part of the intricate immune surveillance system to discriminate among healthy host tissue, dead cells and foreign intruders.

Traditionally, the immune system is divided into two parts: the innate immune system and the adaptive immune system. The adaptive immune system plays a key role in the development of specific antibodies to specific targets. In contrast, the innate immune system reacts in a generic way to patterns of pathogen- or damage-associated molecules. 

The complement system is a complex hub like network of proteins, reactions and processes. More than 40 proteins, fluid-phased, cell-surface associated and intra-cellular proteins functions together to maintain immunosurveillance and homeostasis of our body. If not properly controlled and regulated, the complement system has the potential to harm the host. Therefore, complement activation is precisely modulated in a very specific manner and under control by many regulatory proteins.

 

Complement System Solutions

Svar offers functional and biomarker assays that can be used to explore every angle of complement system-involvement in a wide range of application areas.

• Reliable, objective and easy-to-interpret results
• Results in just a few hours – optimize time usage with Svar's biomarker and functional complement assays
• Low inter-assay variability and excellent reproducibility
• Based on the well-established and flexible ELISA and reporter-gene technology
• Developed by in-house experts in collaboration with key opinion leaders
• Ready-to-use reagents for a streamlined workflow
• Excellent specificity means clear results without false positives
• Only company to offer exploration of all three complement system pathways individually
• Increase the resolution of amplification loop research with the novel functional Factor P assays

 

Wieslab Functional Assays

The Svar functional complement assays under the Wieslab® brand were developed together with a network of global key opinion leaders (KOLs) in 2005 and have since been used to answer the need for an easy to use method of detecting complement deficiencies and to explore the effect of complement targeting drugs. With the novel functional Factor P assay, Svar enables in-depth study of Properdin and the AP amplification loop, essential for the complement response.

Complement targeting drugs can be evaluated by the Wieslab® functional complement assays, for efficacy and potency determination, which has been shown in several scientific papers as well as presented at complement conferences. Scientific papers also suggest an application for the functional assays in monitoring complement drugs during clinical trials. The format of the assays can be used with a wide variety of open systems, individual research protocols and automation. This has made the Wieslab® Complement assays much-appreciated by the biotech and pharma industry. 

The Svar complement functional assay solution is an ELISA based platform that enables determination of specific activity of all three pathways separately without interference from the others. The well established ELISA technology means a robust and standardized assay platform, delivering fast, reliable and objective, easy to interpret results within as little as 3 hours.

 

Available Functional Assay Kits

Art N°	Product Description
EUD-COMPLAP330	WIESLAB® Complement Alternative Pathway
EUD-COMPLCP310	WIESLAB® Complement Classical Pathway
EUD-COMPLMP320	WIESLAB® Complement MBL Pathway
EUD-COMPL300	WIESLAB® Complement Screen
EUD-COMPLFPFRUO	Complement Factor P Functional Assay