Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Conjugation:
PE/CF594
Alternative Names:
BCL5, LAZ3, BCL6A, ZNF51, ZBTB27
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
Flow cytometry: 1X10 6 Daudi cells were intracellularly-stained with PE-CF594 Rabbit IgG isotype control (5 µl/Test,left) or PE-CF594 Rabbit anti-Human BCL6 mAb (A27730,5 µl/Test,right).
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