XRCC1 Rabbit mAb, Unconjugated, Monoclonal

Product Overview

• Article Name: XRCC1 Rabbit mAb, Unconjugated, Monoclonal
• Biozol Catalog Number: ABB-A4135
• Supplier Catalog Number: A4135
• Alternative Catalog Number: ABB-A4135-20UL,ABB-A4135-100UL
• Manufacturer: ABclonal
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, WB
• Species Reactivity: Human
• Immunogen: Synthetic peptide. This information is considered to be commercially sensitive.
• Conjugation: Unconjugated
• Alternative Names: RCC, SCAR26, XRCC1

Product Description

The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

Product Properties

• Clonality: Monoclonal
• Molecular Weight: 69kDa
• NCBI: 7515
• UniProt: P18887
• Purity: Affinity purification
• Target: XRCC1

Application Notes

• Application Dilute: WB,1:500 - 1:1000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Application Notes: Cross-Reactivity: Human,Mouse,Rat. ResearchArea: Epigenetics Nuclear Signaling,DNA Damage Repair,Cancer,Endocrine Metabolism,Nucleotide metabolism. Shipping: Ice Bag

Images

Western blot analysis of various lysates using XRCC1 Rabbit mAb (A4135) at 1:1000 dilution.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25µg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 5s.