Phospho-alpha-Synuclein-S129 Rabbit pAb, Unconjugated

Product Overview

• Article Name: Phospho-alpha-Synuclein-S129 Rabbit pAb, Unconjugated
• Biozol Catalog Number: ABB-AP0450
• Supplier Catalog Number: AP0450
• Alternative Catalog Number: ABB-AP0450-500UL,ABB-AP0450-20UL,ABB-AP0450-1000UL,ABB-AP0450-100UL
• Manufacturer: ABclonal
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, WB
• Species Reactivity: Human
• Immunogen: Synthetic peptide. This information is considered to be commercially sensitive.
• Conjugation: Unconjugated
• Alternative Names: PD1, NACP, PARK1, PARK4, Phospho-alpha-Synuclein-S129

Product Description

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimers disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.

Product Properties

• Clonality: Polyclonal
• Molecular Weight: 14kDa
• NCBI: 6622
• UniProt: P37840
• Purity: Affinity purification
• Sequence: MPSEE
• Target: SNCA
• Antibody Type: Primary Antibody

Application Notes

• Application Dilute: WB,1:500 - 1:2000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Application Notes: Cross-Reactivity: Human,Mouse,Rat, ResearchArea: Protein phosphorylation,Cell Biology Developmental Biology,Apoptosis,Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimers Disease,Dopamine Signaling in Parkinsons Disease,Neurodegenerative Diseases Markers.

Images

Western blot analysis of lysates from mouse brain tissue, using Phospho-alpha-Synuclein-S129 Rabbit pAb (AP0450).
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25µg per lane.
Blocking buffer: 3% BSA.