Phospho-alpha-Synuclein-Y133 Rabbit pAb, Unconjugated

Product Overview

• Article Name: Phospho-alpha-Synuclein-Y133 Rabbit pAb, Unconjugated
• Biozol Catalog Number: ABB-AP0451
• Supplier Catalog Number: AP0451
• Alternative Catalog Number: ABB-AP0451-20UL, ABB-AP0451-100UL
• Manufacturer: ABclonal
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, WB
• Species Reactivity: Human
• Immunogen: Synthetic peptide. This information is considered to be commercially sensitive.
• Conjugation: Unconjugated
• Alternative Names: PD1, NACP, PARK1, PARK4, Phospho-alpha-Synuclein-Y133

Product Description

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimers disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.

Product Properties

• Molecular Weight: 14kDa
• NCBI: 6622
• UniProt: P37840
• Purity: Affinity purification
• Target: SNCA

Application Notes

• Application Dilute: WB,1:500 - 1:2000|ELISA,Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
• Application Notes: Cross-Reactivity: Human,Mouse, ResearchArea: Protein phosphorylation,Cell Biology Developmental Biology,Apoptosis,Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimers Disease,Dopamine Signaling in Parkinsons Disease,Neurodegenerative Diseases Markers.

Images

Western blot analysis of various lysates, using Phospho-alpha-Synuclein-Y133 pAb (AP0451) at 1:1000 dilution. Jurkat and NIH/3T3 cells were treated with Pervanadate (1 mM) at 37°C for 30 minutes.
Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25µg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 60s.