Interleukin?17A (IL?17A), also known as CTLA?8, is a 15?20 kDa glycosylated cytokine that plays an important role in anti?microbial and chronic inflammation. The six IL?17 cytokines (IL?17A?F) are encoded by separate genes but adopt a conserved cystine knot fold .IL-17A is a ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC . Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines.
95 % as determined by Tris-Bis PAGE, 95 % as determined by HPLC.
Target:
IL-17A&F
Application Notes:
Cross-Reactivity: Centrifuge the tube before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage,it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA,5% HSA,10% FBS or 5% Trehalose),and aliquot the reconstituted protein solution to minimize free-thaw cycles., ResearchArea: Other Recombinant Protein
Recombinant Human IL-17A&,amp,IL-17F Protein was determined by Tris-Bis PAGE under reducing conditions.
The purity of Human IL-17A&,F is greater than 95% as determined by SEC-HPLC.
Immobilized Human IL-17A&,F, His Tag at 1µg/ml (100µl/well) on the plate. Dose response curve for Anti-IL-17A Antibody, hFc Tag with the EC<,sub>,50<,/sub>, of 34.0ng/ml determined by ELISA.
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