Recombinant Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, Human

Product Overview

• Article Name: Recombinant Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, Human
• Biozol Catalog Number: ABB-RP02655
• Supplier Catalog Number: RP02655
• Alternative Catalog Number: ABB-RP02655-100UG
• Manufacturer: ABclonal
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Mouse
• Immunogen: Phe31-Val988(ITGAV) acidic tail&Gly22-Asn706(ITGB6) basic tail
• Alternative Names: ITGAV&ITGB6,Integrin alpha V beta 6

Product Description

ITGAV&ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion . ITGAV&ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 .

Product Properties

• Concentration: < 1 EU/µg of the protein by LAL method.
• Molecular Weight: 111.6 kDa (ITGAV) &amp; 79.2 kDa (ITGB6)
• NCBI: 16410
• UniProt: P43406
• Purity: 95 % as determined by Tris-Bis PAGE, 95 % as determined by HPLC.
• Sequence: FNLDVESPAEYAGPEGSYFGFAVDFFEPSTSSRMFLLVGAPKANTTQPGIVEGGQVLKCECSSSRRCQPIEFDSTGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSKNIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIISKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIEDFVSGVPRAARTLGMVYI
• Target: Integrin alpha V beta 6 (ITGAV&amp;ITGB6) Heterodimer

Application Notes

• Application Notes: Cross-Reactivity: Centrifuge the tube before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage,it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA,5% HSA,10% FBS or 5% Trehalose),and aliquot the reconstituted protein solution to minimize free-thaw cycles. ResearchArea: Other Recombinant Protein