Cre (Cyclization Recombination Enzyme) is a 38 kDa DNA recombinase isolated from the P1 bacteriophage. Cre specifically recognizes loxP DNA sequences and mediates site-specific deletion of DNA sequences located between two loxP sites. The Cre-loxP system is primarilyused for gene knockout and can also induce inversion or translocation of DNA sequences depending on the position and orientation of the loxP sites.
