Human B7-H2 / ICOSLG Protein, Fc Tag, Unconjugated
Biozol Catalog Number:
ABS-B72-H5254-100UG
Supplier Catalog Number:
B72-H5254-100ug
Alternative Catalog Number:
ABS-B72-H5254-100UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
ICOS ligand (ICOSLG) is also known as B7 homolog 2 (B7H2), B7related protein 1 (B7RP1) and CD antigen CD275, which belongs to the immunoglobulin superfamily and BTN/MOG family. ICOSLG contains one Iglike C2type (immunoglobulinlike) domain and one Iglike Vtype (immunoglobulinlike) domain. Isoform 1 is widely expressed, while isoform 2 is detected only in lymph nodes, leukocytes and spleen. B7H2 is ligand for the Tcellspecific cell surface receptor ICOS. B7H2 acts as a costimulatory signal for Tcell proliferation and cytokine secretion and induces also Bcell proliferation and differentiation into plasma cells. B7H2 could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by costimulating memory Tcell function. - Proteine/Peptide
