Cynomolgus CRTAM Protein, Fc Tag, Unconjugated, Human

Product Overview

• Article Name: Cynomolgus CRTAM Protein, Fc Tag, Unconjugated, Human
• Biozol Catalog Number: ABS-CRM-C5255-100UG
• Supplier Catalog Number: CRM-C5255-100ug
• Alternative Catalog Number: ABS-CRM-C5255-100UG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Monkey
• Conjugation: Unconjugated

Product Description

Class Irestricted T cellassociated molecule (CRTAM), a member of nectin family and the immunoglobulin superfamily, is also known as cytotoxic and regulatory Tcell molecule, which is expressed by activated CD8+ and NK T cells. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and surprisingly, in brain where it is highly expressed by Purkinje cells of the cerebellum. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions (3 5). IGSF4 and T cell receptor coengagement of CRTAMexpressing CD8+ cells induces increased IFNgamma or IL22 production (3, 4). Furthermore, a role in cancer surveillance through NK cellmediated rejection of IGSF4expressing tumors has been proposed. - Proteine/Peptide

Product Properties

• Molecular Weight: 56.6 kDa
• Tag: C-Fc
• NCBI: 005580021
• Buffer: Tris with Glycine, Arginine and NaCl, pH7.5
• Purity: 95%
• Form: Powder
• Target: CRTAM

Images

CRM-C5255-100ug

Immobilized Human CADM1, His Tag (Cat. No. CA1-H5225) at 5 µg/mL (100 µL/well) can bind Cynomolgus CRTAM, Fc Tag (Cat. No. CRM-C5255) with a linear range of 0.6-10 ng/mL (QC tested).

Cynomolgus CRTAM, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.