Human FUS Protein, MBP,His Tag, Unconjugated, E. coli
Biozol Catalog Number:
ABS-FUS-H5144-100UG
Supplier Catalog Number:
FUS-H5144-100ug
Alternative Catalog Number:
ABS-FUS-H5144-100UG
Manufacturer:
AcroBiosystems
Host:
E. coli
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
FUS (RNAbinding protein FUS) is a DNA/RNAbinding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. It binds to nascent premRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing. It binds also its own premRNA and autoregulates its expression, this autoregulation mechanism is mediated by nonsensemediated decay. FUS plays a role in DNA repair mechanisms by promoting Dloop formation and homologous recombination during DNA doublestrand break repair. In neuronal cells, FUS plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis. - Proteine/Peptide
