Human Parkin Protein, His Tag, Unconjugated, Insect 500 ug

Product Overview

• Article Name: Human Parkin Protein, His Tag, Unconjugated, Insect 500 ug
• Biozol Catalog Number: ABS-PAN-H5543-500UG
• Supplier Catalog Number: PAN-H5543-500ug
• Alternative Catalog Number: ABS-PAN-H5543-500UG
• Manufacturer: AcroBiosystems
• Host: Insect
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

Parkin is an E3 ubiquitin ligase encoded by the PARK2 gene, comprising 465 amino acids and containing an N-terminal ubiquitin-like domain and C-terminal RING domains. It plays a pivotal role in the ubiquitin-proteasome system, tagging damaged or misfolded proteins for degradation. Parkin is essential for mitophagy, the selective clearance of dysfunctional mitochondria, thereby maintaining cellular homeostasis. Mutations in PARK2 cause autosomal recessive juvenile Parkinsons disease, leading to dopaminergic neuron loss. Beyond neuroprotection, Parkin influences apoptosis regulation and cellular stress responses. Its dysfunction is linked to mitochondrial impairment, protein aggregation, and neurodegeneration, making it a key target in Parkinsons disease research - Proteine/Peptide

Product Properties

• Molecular Weight: 53.5 kDa
• Tag: N-10*His
• NCBI: 60260
• Buffer: 50 mM Tris, 150 mM NaCl, pH7.5
• Purity: 85%
• Form: Liquid
• Target: Parkin

Images

Human Parkin Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 85%.