Anti-Beta-Defensin Antibody, Rabbit, Polyclonal
Catalog Number:
ABT-AN2090
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| Article Name: | Anti-Beta-Defensin Antibody, Rabbit, Polyclonal |
| Biozol Catalog Number: | ABT-AN2090 |
| Supplier Catalog Number: | AN2090 |
| Alternative Catalog Number: | ABT-AN2090-100UL |
| Manufacturer: | Abcepta |
| Host: | Rabbit |
| Category: | Antikörper |
| Alternative Names: | DEFB1, BD1, Defensin beta 1 preproprotein, HBD |
| A novel, nonhemolytic antimicrobial peptide (human beta-defensin-3, hBD-3) was isolated from human lesional psoriatic scales and cloned from keratinocytes. hBD-3 demonstrated a salt-insensitive broad spectrum of potent antimicrobial activity against many potentially pathogenic microbes including multiresistant S. aureus and vancomycin-resistant Enterococcus faecium. Keratinocytes and airway epithelial cells are cellular sources of hBD-3. Tumor necrosis factor alpha and contact with bacteria were found to induce hBD-3 mRNA expression. hBD-3 therefore might be important in the innate epithelial defense of infections by various microorganisms seen in skin and lung, such as cystic fibrosis. |
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