Anti-TRAIL R2 (DR5) Antibody, Rabbit, Polyclonal
Catalog Number:
ABT-AN2125
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| Article Name: | Anti-TRAIL R2 (DR5) Antibody, Rabbit, Polyclonal |
| Biozol Catalog Number: | ABT-AN2125 |
| Supplier Catalog Number: | AN2125 |
| Alternative Catalog Number: | ABT-AN2125-100UL |
| Manufacturer: | Abcepta |
| Host: | Rabbit |
| Category: | Antikörper |
| Alternative Names: | TNFRSF10B, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9, UNQ160/PRO186 |
| TRAIL (also known as Apo-2L) is a member of the tumor necrosis factor (TNF) ligand family that rapidly induces apoptosis in a variety of transformed cell lines. A distinct receptor for TRAIL, TRAIL-R2 (aka Death Receptor 5 (DR5)), by ligand-based affinity purification and subsequent molecular cloning. TRAIL-R2 is widely expressed and the gene encoding TRAIL-R2 is located on human chromosome 8p22-21. TRAIL-R2 engages a caspase-dependent apoptotic pathway but, in contrast to TRAIL-R1, TRAIL-R2 mediates apoptosis via the intracellular adaptor molecule FADD/MORT1. |
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