Anti-PRG3 Antibody, Rabbit, Polyclonal
Catalog Number:
ABT-AN2136
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| Article Name: | Anti-PRG3 Antibody, Rabbit, Polyclonal |
| Biozol Catalog Number: | ABT-AN2136 |
| Supplier Catalog Number: | AN2136 |
| Alternative Catalog Number: | ABT-AN2136-100UL |
| Manufacturer: | Abcepta |
| Host: | Rabbit |
| Category: | Antikörper |
| Alternative Names: | Proteoglycan 3, Eosinophil major basic protein homolog, Prepro-major basic protein homolog, Prepro-MBPH |
| The p53 tumor suppressor protein induces cell cycle arrest or apoptosis in response to cellular stresses. PRG3 (p53-responsive gene 3), is induced specifically under p53-dependent apoptotic conditions in human colon cancer cells. PRG3 has significant homology to bacterial oxidoreductases and the apoptosis-inducing factor, AIF. Unlike AIF, PRG3 localizes in the cytoplasm and its ectopic expression induces apoptosis. The PRG3 gene is thus a novel p53 target gene in a p53-dependent apoptosis pathway |
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