Fludarabine (NSC 118218) is a STAT1 activation inhibitor and a DNA synthesis inhibitor. Fludarabine inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase. Fludarabine markedly inhibited VSMC proliferation in cell culture. Fludarabine also induces significant reduction of STAT-1 phosphorylation, whereas it does not change JAK2 activation. Fludarabine exhibits antiproliferative activity (IC50 = 1.54 µM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression.
Molecular Weight:
285.23
Purity:
100.00%
CAS Number:
[21679-14-1]
Formula:
C10H12FN5O4
Target:
STAT
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