GSK5182 is a 4-Hydroxytamoxifen analog and a highly potent, selective, orally active estrogen-related receptor gamma (ERRgamma) inverse agonist with an IC50 value of 79 nM.GSK5182 does not interact with other nuclear receptors, including ERRalpha and ERalpha. In addition, GSK5182 inhibits proinflammatory cytokine-induced catabolic factors and increases ROS production in liver cancer cells. cytokine-induced catabolic factors and increased ROS production in hepatocellular carcinoma cells.
Molecular Weight:
417.54
Purity:
>99%
CAS Number:
[877387-37-6]
Formula:
C27H31NO3
Target:
Estrogen Receptor
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