Picropodophyllin (AXL1717), CAS [[477-47-4]]

Product Overview

• Article Name: Picropodophyllin (AXL1717), CAS [[477-47-4]]
• Biozol Catalog Number: AMO-M2411
• Supplier Catalog Number: M2411
• Alternative Catalog Number: AMO-M2411-1MG,AMO-M2411-5MG,AMO-M2411-10MG,AMO-M2411-50MG
• Manufacturer: Abmole Bioscience
• Category: Biochemikalien
• Alternative Names: Picropodophyllotoxin, CAS 17434-18-3, PPP

Product Description

AXL1717 (picropodophyllin, Picropodophyllotoxin, PPP) is a non-competitive, potent, and specific inhibitor of IGF-1Ralpha/beta with IC50 of 1 nM. Picropodophyllin binds to the intracellular tyrosine kinase domain of IGF-1R, inducing a conformational shift to an inactive state, thereby effectively inhibiting its autophosphorylation and downstream signal transduction.

Product Properties

• Molecular Weight: 414.41
• Purity: >99%
• CAS Number: [477-47-4]
• Formula: C22H22O8
• Target: IGF-1R