Resmetirom (MGL-3196, VIA-3196, resmetirom) is a potentially first-in-class, liver-targeted, orally active, selective thyroid hormone receptor (THR)-beta agonist with an EC50 value of 0.21 µM. Resmetirom avoids the activation of THR-alpha receptors that mediate thyroid hormone activity outside of the liver, including the heart and bone. Resmetirom avoids the activation of THR-alpha receptors that mediate extrahepatic (including cardiac and skeletal) thyroid hormone activity and can be used in studies of non-alcoholic steatohepatitis (NASH).
Molecular Weight:
435.22
Purity:
99.87%
CAS Number:
[920509-32-6]
Formula:
C17H12Cl2N6O4
Target:
Thyroid Hormone Receptor
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