CASP1 Antibody - middle region

Product Overview

• Article Name: CASP1 Antibody - middle region
• Biozol Catalog Number: ASB-ARP97640_P050
• Supplier Catalog Number: ARP97640_P050
• Alternative Catalog Number: ASB-ARP97640_P050-25UL,ASB-ARP97640_P050-100UL
• Manufacturer: Aviva
• Host: Rabbit
• Category: Proteine/Peptide
• Application: WB
• Species Reactivity: Mouse
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of mouse CASP1
• Alternative Names: IC, ICE, Il1, Casp, Il1bc

Product Description

Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive.

Product Properties

• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Molecular Weight: 44 kDa
• NCBI: 12362
• UniProt: P29452
• Form: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.