NFATC1 antibody - N-terminal region (P100981_P050), Rabbit, Polyclonal
Biozol Catalog Number:
ASB-P100981_P050
Supplier Catalog Number:
P100981_P050
Alternative Catalog Number:
ASB-P100981_P050-100UL, ASB-P100981_P050-25UL
Manufacturer:
Aviva
Host:
Rabbit
Category:
Antikörper
Application:
IHC, WB
Species Reactivity:
Canine, Guinea pig, Human, Mouse
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human NFATC1
Alternative Names:
NFAT2, NFATc, NF-ATC, NF-ATc1.2
NFATC1 is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Different isoforms of this protein may regulate inducible expression of different cytokine genes. The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.
