Langerin / CD207 (Marker of Langerhans Cells)(rLGRN/1821), 1mg/mL
Biozol Catalog Number:
BOT-BNUM3608-50
Supplier Catalog Number:
BNUM3608-50
Alternative Catalog Number:
BOT-BNUM3608-50-50UL
Manufacturer:
Biotium
Category:
Antikörper
Species Reactivity:
Mouse
Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2 -dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG). BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Concentration:
1 mg/mL
Buffer:
PBS, no BSA, no azide
Source:
Animal
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