ALKBH5 Polyclonal Antibody, Biotin Conjugated, Rabbit

Product Overview

• Article Name: ALKBH5 Polyclonal Antibody, Biotin Conjugated, Rabbit
• Biozol Catalog Number: BSS-BS-20540R-BIOTIN
• Supplier Catalog Number: bs-20540R-Biotin
• Alternative Catalog Number: BSS-BS-20540R-BIOTIN-100
• Manufacturer: Bioss
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, IHC-Fr, IHC-P
• Species Reactivity: Mouse, Rat
• Conjugation: Biotin
• Alternative Names: ABH5, AlkB, alkylation repair homolog 5 (E. coli), AlkB, alkylation repair homolog 5, Alkylated DNA repair protein alkB homolog 5, Alpha ketoglutarate dependent dioxygenase alkB homolog 5, OFOXD, OFOXD1, Oxoglutarate and iron-dependent oxygenase domain containing, Probable alpha ketoglutarate dependent dioxygenase ABH5, RNA demethylase ALKBH5.

Product Description

Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A)RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24778178,PubMed:24616105, PubMed:24489119). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro)(PubMed:24616105). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24778178,PubMed:24616105, PubMed:24489119). Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736). Required for spermatogenesis (By similarity).

Product Properties

• Clonality: Polyclonal
• Concentration: 1ug/ul
• NCBI: 54890
• UniProt: Q6P6C2
• Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
• Source: KLH conjugated synthetic peptide derived from human ALKBH5
• Purity: Purified by Protein A.
• Target: ALKBH5
• Antibody Type: Primary Antibody

Application Notes

• Application Dilute: ELISA(1:500-1000), IHC-P(1:200-400), IHC-F(1:100-500)