UNC0642 --- G9a/GLP HMTase Inhibitor, CAS [[1481677-78-4]], Unconjugated
Biozol Catalog Number:
BSS-BS-60185C
Supplier Catalog Number:
bs-60185C
Alternative Catalog Number:
BSS-BS-60185C-10,BSS-BS-60185C-2
Manufacturer:
Bioss
Category:
Biochemikalien
Conjugation:
Unconjugated
UNC0642 is a novel highly potent, selective and cell permeable inhibitor of the homologous protein lysine methyltransferases, G9a and GLP, with IC50 < 2.5 nM. It has selectivity > 1000-fold over 13 other HMTs and selected representatives of kinases, ion channels, 7TMs, and other epigenetic proteins. UNC0642 reduces H3K9 dimethylation levels in MDA-MB-231 cells (IC50~110 nM). It has improved PK properties relative to UNC0638 and displayed modest brain penetration in vivo.
Buffer:
Powder
CAS Number:
[1481677-78-4]
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