Bub3 Polyclonal Antibody, Biotin Conjugated, Rabbit

Product Overview

• Article Name: Bub3 Polyclonal Antibody, Biotin Conjugated, Rabbit
• Biozol Catalog Number: BSS-BS-7835R-BIOTIN
• Supplier Catalog Number: bs-7835R-Biotin
• Alternative Catalog Number: BSS-BS-7835R-BIOTIN-100
• Manufacturer: Bioss
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, IHC-Fr, IHC-P, WB
• Species Reactivity: Rat
• Conjugation: Biotin
• Alternative Names: BUB3L, hBUB3, Mitotic checkpoint protein BUB3, BUB3

Product Description

Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.

Product Properties

• Clonality: Polyclonal
• Concentration: 1ug/ul
• NCBI: 9184
• UniProt: O43684
• Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
• Source: KLH conjugated synthetic peptide derived from human Bub3
• Target: Bub3

Application Notes

• Application Dilute: WB(1:300-5000), ELISA(1:500-1000), IHC-P(1:200-400), IHC-F(1:100-500)