PCNA Monoclonal Antibody, Biotin Conjugated, Clone: [2A1], Mouse
Catalog Number:
BSS-BSM-10889M-BIOTIN
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| Article Name: | PCNA Monoclonal Antibody, Biotin Conjugated, Clone: [2A1], Mouse |
| Biozol Catalog Number: | BSS-BSM-10889M-BIOTIN |
| Supplier Catalog Number: | bsm-10889M-Biotin |
| Alternative Catalog Number: | BSS-BSM-10889M-BIOTIN-100 |
| Manufacturer: | Bioss |
| Host: | Mouse |
| Category: | Antikörper |
| Application: | IHC-Fr, IHC-P, WB |
| Species Reactivity: | Human, Mouse, Rat |
| Conjugation: | Biotin |
| Alternative Names: | Cyclin, DNA polymerase delta auxiliary protein, HGCN8729, MGC8367, Mutagen-sensitive 209 protein, Pcna/cyclin, PCNAR, Polymerase delta accessory protein, Proliferating Cell Nuclear Antigen, PCNA_HUMAN. |
| Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of eukaryotic DNA replication by increasing the polymerases processibility during elongation of the leading strand (PubMed:35585232). Induces a robust stimulatory effect on the 3-5 exonuclease and 3-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while Lys-63-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion (PubMed:24695737). |
| Clonality: | Monoclonal |
| Concentration: | 1ug/ul |
| Clone Designation: | [2A1] |
| NCBI: | 5111 |
| Buffer: | Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Source: | Recombinant human PCNA Protein |
| Target: | PCNA |
| Application Dilute: | WB(1:300-5000), IHC-P(1:200-400), IHC-F(1:100-500) |
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