Hamartin Rabbit monoclonal antibody, Unconjugated

Product Overview

• Article Name: Hamartin Rabbit monoclonal antibody, Unconjugated
• Biozol Catalog Number: BWT-BS41107
• Supplier Catalog Number: BS41107
• Alternative Catalog Number: BWT-BS41107-50UL,BWT-BS41107-100UL
• Manufacturer: Bioworld Technology
• Host: Rabbit
• Category: Antikörper
• Application: FC, ICC, IHC, WB
• Species Reactivity: Human
• Immunogen: A synthesized peptide derived from human Hamartin
• Conjugation: Unconjugated
• Alternative Names: Hamartin, kiaa0243, LAM, TSC, Tsc1, Tuberous sclerosis 1,

Product Description

In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.

Product Properties

• Molecular Weight: 150kDa
• UniProt: Q92574
• Purity: Affinity-chromatography
• Form: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Application Notes

• Application Dilute: WB 1:1000~1:5000 IHC 1:50~1:200 ICC/IF 1:50~1:200 FC 1:200
• Application Notes: Hamartin Antibody detects endogenous levels of total Hamartin