Caspase 5 p10 polyclonal antibody, Unconjugated, Rabbit

Product Overview

• Article Name: Caspase 5 p10 polyclonal antibody, Unconjugated, Rabbit
• Biozol Catalog Number: BWT-BS5645
• Supplier Catalog Number: BS5645
• Alternative Catalog Number: BWT-BS5645-50UL,BWT-BS5645-100UL
• Manufacturer: Bioworld Technology
• Host: Rabbit
• Category: Antikörper
• Application: WB
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide, corresponding to amino acids 341-386 of Human Caspase-5.
• Conjugation: Unconjugated
• Alternative Names: Caspase-5, CASP-5, ICE(rel)-III, Protease ICH-3, Protease TY, Caspase-5 subunit p10, CASP5, ICH3, Caspase5

Product Description

Caspase-5 (also designated ICErel-III, TY, ICH-3 and caspase-12 in mouse), can cleave its own precursor, an activity that requires the cysteine 245 residue. Frameshift mutations in caspase-5 have been identified in MMP tumors of the endometrium, colon, and stomach, indicating the caspase-5 may be a new target gene in the microsatellite mutator pathway for cancer. The human caspase 5 gene maps to chromosome 11q22.2-q22.3 and encodes a protein whose expression is barely detectable in most tissues except brain, with highest expression levels being found in lung, liver and skeletal muscle.

Product Properties

• Molecular Weight: ~ 10, 48 kDa
• UniProt: P51878
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
• Form: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Application Notes

• Application Dilute: WB: 1:500~1:1000
• Application Notes: Caspase 5 p10 polyclonal antibody recognizes endogenous levels of total caspase-5 protein and the p10 subunit of mature caspase-5.