IC 86621, CAS [[404009-40-1]]

Product Overview

• Article Name: IC 86621, CAS [[404009-40-1]]
• Biozol Catalog Number: BYT-ORB1297892
• Supplier Catalog Number: orb1297892
• Alternative Catalog Number: BYT-ORB1297892-1, BYT-ORB1297892-10, BYT-ORB1297892-100, BYT-ORB1297892-25, BYT-ORB1297892-5, BYT-ORB1297892-50
• Manufacturer: Biorbyt
• Category: Biochemikalien
• Alternative Names: DNA-dependent protein kinase, DNAPK, DNA-PK, DSB, Buchwald-Hartwig amination, ATP, Apoptosis, antitumor, Fries rearrangement, Inhibitor, IC 86621, IC86621, IC-86621, inhibit

Product Description

IC 86621 is a potent, selective, and reversible ATP-competitive inhibitor of DNA-PK, exhibiting an IC50 of 120 nM. It disrupts DNA double-strand break repair with an EC50 of 68 µM in cellular assays, enhancing the antitumor effects of DNA-damaging agents in cancer research models, both in vitro and in vivo.

Product Properties

• Molecular Weight: 221.25
• Purity: 99.68% (May vary between batches)
• CAS Number: [404009-40-1]
• Formula: C12H15NO3
• Target: Apoptosis,DNA-PK

Application Notes

• Application Notes: Solubility: DMSO:50 mg/mL (225.99 mM),10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.04 mM)