API-1, CAS [[36707-00-3]]

Product Overview

• Article Name: API-1, CAS [[36707-00-3]]
• Biozol Catalog Number: BYT-ORB1298484
• Supplier Catalog Number: orb1298484
• Alternative Catalog Number: BYT-ORB1298484-1, BYT-ORB1298484-1, BYT-ORB1298484-10, BYT-ORB1298484-100, BYT-ORB1298484-200, BYT-ORB1298484-25, BYT-ORB1298484-5, BYT-ORB1298484-50
• Manufacturer: Biorbyt
• Category: Biochemikalien
• Alternative Names: inhibit, NSC 177223, NSC177223, NSC-177223, Inhibitor, Akt, Akt/PKB inhibitor, Apoptosis, API 1, API1, API-1, Protein kinase B, PKB, TRAIL

Product Description

API-1 (NSC-177223) is a selective Akt inhibitor that promotes apoptosis by triggering GSK3beta-dependent, beta-TrCP/FBXW7-mediated degradation of the anti-apoptotic protein Mcl-1. This mechanism supports its application in cancer research, particularly for studying apoptosis resistance in vitro and evaluating therapeutic potential in vivo.

Product Properties

• Molecular Weight: 337.29
• Purity: 99.07% (May vary between batches)
• CAS Number: [36707-00-3]
• Formula: C13H15N5O6
• Target: Caspase,Akt,PARP,Apoptosis

Application Notes

• Application Notes: Solubility: DMSO:22.5 mg/mL (66.71 mM),10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.93 mM)