cancer, Inhibitor, K Ras PDEdelta IN 1, inhibit, K-Ras-PDEdelta-IN-1, KRasPDEdeltaIN1, K-Ras-PDEdelta-IN-1, PDEdelta, PDE, phosphodiesterase, Phosphodiesterase (PDE), pyrazolopyridazinone-based
K-Ras-PDEdelta-IN-1 is a high-affinity inhibitor (Kd = 8 nM) that targets the farnesyl-binding site of PDEdelta, disrupting the K-Ras-PDEdelta interaction. This tool compound is valuable for in vitro biochemical studies and cellular research exploring oncogenic Ras signaling pathways and potential therapeutic strategies.
Molecular Weight:
447.5
Purity:
99.74% (May vary between batches)
CAS Number:
[1841464-21-8]
Formula:
C25H26FN5O2
Target:
PDE
Application Notes:
Solubility: DMSO:4.48 mg/mL (10.01 mM)
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