Theliatinib, CAS [[1353644-70-8]]

Product Overview

• Article Name: Theliatinib, CAS [[1353644-70-8]]
• Biozol Catalog Number: BYT-ORB1299921
• Supplier Catalog Number: orb1299921
• Alternative Catalog Number: BYT-ORB1299921-1, BYT-ORB1299921-1, BYT-ORB1299921-10, BYT-ORB1299921-100, BYT-ORB1299921-25, BYT-ORB1299921-5, BYT-ORB1299921-50
• Manufacturer: Biorbyt
• Category: Biochemikalien
• Alternative Names: HMPL309, HMPL-309, HMPL 309, Inhibitor, HER1, ERK, esophageal, ErbB-1, Epidermal growth factor receptor, EGFR, inhibit, orally, anti-tumor, ATP-competitive, cancer, AKT, Theliatinib, Xiliertinib, phosphorylation

Product Description

Theliatinib is a potent and highly selective EGFR inhibitor, exhibiting a Ki of 0.05 nM for wild-type EGFR. It demonstrates anti-tumor activity in research models, with IC50 values of 3 nM and 22 nM against EGFR and the EGFR T790M/L858R mutant, respectively. This compound is applied in preclinical oncology research for investigating EGFR-driven cancers both in vitro and in vivo.

Product Properties

• Molecular Weight: 442.51
• Purity: 99.67% (May vary between batches)
• CAS Number: [1353644-70-8]
• Formula: C25H26N6O2
• Target: EGFR

Application Notes

• Application Notes: Solubility: DMSO:47 mg/mL (106.21 mM)