Refametinib, CAS [[923032-37-5]]

Product Overview

• Article Name: Refametinib, CAS [[923032-37-5]]
• Biozol Catalog Number: BYT-ORB1300596
• Supplier Catalog Number: orb1300596
• Alternative Catalog Number: BYT-ORB1300596-1,BYT-ORB1300596-10,BYT-ORB1300596-100,BYT-ORB1300596-2,BYT-ORB1300596-200,BYT-ORB1300596-25,BYT-ORB1300596-5,BYT-ORB1300596-50
• Manufacturer: Biorbyt
• Category: Biochemikalien
• Alternative Names: tumor, RDEA119, RDEA-119, Refametinib, RDEA 119, MAP2K, MAPKK, MEK, MEK1, MEK2, Inhibitor, inhibit, Mitogen-activated protein kinase kinase, orally, BAY 869766, BAY 86-97661, BAY869766, BAY-869766, allosteric

Product Description

Refametinib (RDEA119) is a potent and selective, ATP-noncompetitive inhibitor of MEK1 and MEK2 kinases, exhibiting IC50 values of 19 nM and 47 nM, respectively. It is widely used in cancer research, demonstrating antitumor activity in both in vitro cellular assays and in vivo models of various malignancies.

Product Properties

• Molecular Weight: 572.34
• Purity: >99.99% (May vary between batches)
• CAS Number: [923032-37-5]
• Formula: C19H20F3IN2O5S
• Target: MEK

Application Notes

• Application Notes: Solubility: Ethanol:93 mg/mL (162.49 mM),DMSO:150 mg/mL (262.08 mM),H2O:< 1 mg/mL (insoluble or slightly soluble)