Encorafenib, CAS [[1269440-17-6]]

Product Overview

• Article Name: Encorafenib, CAS [[1269440-17-6]]
• Biozol Catalog Number: BYT-ORB1300725
• Supplier Catalog Number: orb1300725
• Alternative Catalog Number: BYT-ORB1300725-1, BYT-ORB1300725-10, BYT-ORB1300725-25, BYT-ORB1300725-5, BYT-ORB1300725-50
• Manufacturer: Biorbyt
• Category: Biochemikalien
• Alternative Names: Raf, Raf kinases, B-Raf (V600E), Inhibitor, LGX 818, LGX818, LGX-818, Encorafenib, inhibit

Product Description

Encorafenib (LGX818) is a potent and selective oral inhibitor of the BRAF V600E mutation, with an IC50 of 0.3 nM. It is widely used in preclinical oncology research, demonstrating significant antitumor activity in both in vitro cellular assays and in vivo models of melanoma and colorectal cancer.

Product Properties

• Molecular Weight: 540.01
• Purity: 99.83% (May vary between batches)
• CAS Number: [1269440-17-6]
• Formula: C22H27ClFN7O4S
• Target: Raf

Application Notes

• Application Notes: Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble),10% DMSO+40% PEG300+5% Tween 80+45% Saline:9.3 mg/mL (17.22 mM),DMSO:257 mg/mL (475.92 mM),Ethanol:93 mg/mL (172.22 mM)