PHPS1 is a potent and selective Shp2 inhibitor that suppresses the oncogenic Shp2-E76K mutant-driven Erk1/2 activation. It effectively inhibits the anchorage-independent proliferation of various human cancer cell lines in vitro, making it a valuable chemical probe for studying Shp2 signaling in oncology research.
Molecular Weight:
465.44
Purity:
99.77% (May vary between batches)
CAS Number:
[314291-83-3]
Formula:
C21H15N5O6S
Target:
Phosphatase
Application Notes:
Solubility: DMSO:16.25 mg/mL (34.91 mM)
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