Amyloid-Forming peptide GNNQQNY, CAS [[339091-39-3]] Preis auf Anfrage
Biozol Catalog Number:
BYT-ORB1941648
Supplier Catalog Number:
orb1941648
Alternative Catalog Number:
BYT-ORB1941648-5,BYT-ORB1941648-50
Manufacturer:
Biorbyt
Category:
Biochemikalien
Amyloid-Forming peptide GNNQQNY, a biologically active heptapeptide derived from the N-terminal prion-determining domain of yeast Sup35, is instrumental in amyloid fibril formation. Its atomic oligomeric structure has been detailed, serving as an excellent model for investigating early-stage aggregation. The peptide can form three stable beta-sheet structures: in-register parallel, off-register parallel, and anti-parallel. Notably, the in-register parallel dimer aligns closely with amyloid beta-sheet architecture, relying on fewer interpeptide hydrogen bonds and emphasizing hydrophobic interactions, which enhances conformational entropy relative to the anti-parallel arrangement.
Molecular Weight:
836.81
CAS Number:
[339091-39-3]
Formula:
C33H48N12O14
Target:
Beta Amyloid
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