Motapizone (NAT 05-239) is a selective phosphodiesterase 3 (PDE3) inhibitor. It elevates intracellular cAMP levels, leading to the suppression of cytokine release in LPS-stimulated human alveolar macrophages and inhibition of human platelet aggregation. This mechanism supports its research applications in studying inflammatory lung diseases and thrombosis in both cellular and animal models.
Molecular Weight:
260.32
Purity:
95.26% (May vary between batches)
CAS Number:
[90697-57-7]
Formula:
C12H12N4OS
Target:
Others,Platelet aggregation,PDE,cAMP
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