Dot1L-IN-1 TFA is a highly potent and selective Dot1L inhibitor with sub-nanomolar activity. It effectively reduces H3K79 dimethylation and suppresses HoxA9 promoter activity in cellular assays, making it a valuable chemical probe for epigenetic research in oncology and hematology, including studies of MLL-rearranged leukemia.
Molecular Weight:
760.23
Formula:
C34H37ClF3N9O4S
Target:
Histone Methyltransferase,Others
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