VHL Ligand-Linker Conjugates 17 are bifunctional chemical tools consisting of a VHL E3 ligase ligand connected to a linker, designed for constructing PROTAC degraders. They serve as key intermediates in synthesizing potent degraders like ARD-266, which effectively degrades the androgen receptor in cancer research, as demonstrated in both cellular and in vivo studies.
Molecular Weight:
654.75
Formula:
C37H42N4O7
Target:
Others,E3 Ligase Ligand-Linker Conjugates
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