PROTAC BTK Degraders-5 (Compound 3e) is a selective Brutons tyrosine kinase (BTK) degrader with a DC50 of 7.0 nM in JeKo-1 cells, demonstrating specificity by not affecting CRBN neosubstrates. It also exhibits antiproliferative effects on various lymphoma cell lines, underscoring its potential application in chronic lymphoid malignancies research.
Molecular Weight:
958.52
Formula:
C52H57ClFN9O6
Target:
BTK
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