SB-1295, an orally active CDK9/T1 inhibitor with an IC50 of 0.17 µM, exhibits antiproliferative effects on HCT 116 and MIA PaCa-2 cells. It promotes cell death in MIA PaCa-2 by elevating intracellular ROS levels, diminishing mitochondrial membrane potential, and triggering apoptosis. This compound holds potential for cancer research.
Molecular Weight:
443.88
Formula:
C23H22ClNO6
Target:
Reactive Oxygen Species
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