JPS016 is a benzamide-based VHL-recruiting PROTAC that induces potent degradation of class I HDACs, specifically HDAC1 and HDAC2. This degradation leads to altered gene expression and enhanced apoptosis in cellular models like HCT116, supporting its use as a chemical probe for oncology and epigenetics research.
Molecular Weight:
1012.14
Formula:
C50H64F3N7O10S
Target:
HDAC,PROTACs
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