Val-Ala-PAB-MMAE, CAS [[1912408-92-4]]

Product Overview

• Article Name: Val-Ala-PAB-MMAE, CAS [[1912408-92-4]]
• Biozol Catalog Number: BYT-ORB2279056
• Supplier Catalog Number: orb2279056
• Alternative Catalog Number: BYT-ORB2279056-1,BYT-ORB2279056-10,BYT-ORB2279056-25,BYT-ORB2279056-5,BYT-ORB2279056-50
• Manufacturer: Biorbyt
• Category: Biochemikalien
• Alternative Names: DrugLinkerConjugatesforADC, DrugLinker Conjugates for ADC

Product Description

Val-Ala-PAB-MMAE is a cathepsin B-cleavable ADC linker-payload conjugate. Upon intracellular cleavage, it releases the cytotoxic agent MMAE to disrupt microtubule assembly, inducing apoptosis in targeted cells. This construct is widely used in ADC research for evaluating antitumor efficacy in both in vitro and in vivo models.

Product Properties

• Molecular Weight: 1037.33
• Purity: 99.02% (May vary between batches)
• CAS Number: [1912408-92-4]
• Formula: C55H88N8O11
• Target: Microtubule Associated,Drug-Linker Conjugates for ADC

Application Notes

• Application Notes: Solubility: DMSO:80 mg/mL (77.12 mM),10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (3.18 mM)