PROTAC PARP1 degrader-3 (C6) is a potent and selective degrader of PARP1 (DC50 = 58.14 nM). It demonstrates cytotoxic activity in colon cancer cell lines like SW-620 and LOVO and shows synergistic effects with SN-38 in BRCA-mutated models, supporting its use in targeted protein degradation and combination therapy research.
Molecular Weight:
896.13
Formula:
C52H65N9O5
Target:
PROTACs,PARP
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