PARL-IN-2 (Compound 14) is a potent covalent inhibitor of the mitochondrial protease PARL (EC50 = 0.16 µM). Its inhibition robustly activates the PINK1/Parkin pathway, promoting mitophagy, and it serves as a critical research tool for studying mitochondrial quality control in cellular models.
Molecular Weight:
365.42
Formula:
C22H23NO4
Target:
Mitophagy,PTEN
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