AGU654 (Compound 44) is a potent and selective mPGES-1 inhibitor (IC50 = 2.9 nM) that suppresses PGE2 production in vitro in human macrophages and whole blood, and demonstrates anti-inflammatory, analgesic, and antipyretic efficacy in guinea pig models, supporting its use for researching inflammatory diseases and pain.
Molecular Weight:
580.91
CAS Number:
[3038861-74-1]
Formula:
C27H19ClF6N4O2
Target:
PGE Synthase
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